The first occurrence of every item in this pool is removed from the Treasure Room Pool. I’ll rank the top three for each category: I would rate Sacred Heart as the best one. They trend defensive offensive items are almost always better than defensive ones.
Mega and Bobby-Bomb to the Treasure Room pool. Obtaining Pretty Fly by using a Slot Machine or through a pill: Halo of FliesĪdditionally, obtaining the Rosary will add seven copies of The Bible to the Shop Pool, and obtaining Dr.Obtaining Spirit of the Night / Dead Dove: Ouija Board.Obtaining Ipecac / Polyphemus / Mutant Spider: The Inner Eye.Finishing an Eternal Heart / Making a deal with Satan: Lunch.Using a Range Up / Down pill: Mom's Lipstick.Using a Tears Up / Down pill: Wire Coat Hanger!.Using a Speed Up / Down pill: Wooden Spoon.In the list below, the first event prevents the player from obtaining the item that follows. In order to decrease redundancy, certain items can be removed from pools even if they are not picked up.
My Little Unicorn in the Secret Room) will not remove it from the Treasure Room Pool, but will instead make it so that that item cannot appear in the Treasure Room Pool therefore, touching more than 5 items that are in the Treasure Room and another pool in the other pool will prevent the Treasure Room Pool from being able to refresh and mean that the game will crash when it runs out of items. In certain cases, however, the game will crash this is because with items that are in both the Treasure Room Pool and another pool, picking that item up in the other pool, (e.g. Depleting the Treasure Room Pool to 5 items or less will cause it to be refreshed. Depleting the Boss Pool will force the use of the Secret Room Pool depleting all others forces the use of the normal Treasure Room Pool instead. Whenever an item is picked up, it is removed from the pool that spawned it seeing the item will result in one copy of the item being removed. For example, a Secret Room will draw from the Secret Room Pool when it contains an item or an item is rerolled inside of it. When an item is to be created, it is selected from the corresponding pool.